Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.

Freidinger, R M; Williams, P D; Tung, R D; Bock, M G; Pettibone, D J; Clineschmidt, B V; DiPardo, R M; Erb, J M; Garsky, V M; Gould, N P

Freidinger, R M; Williams, P D; Tung, R D; Bock, M G; Pettibone, D J; Clineschmidt, B V; DiPardo, R M; Erb, J M; Garsky, V M; Gould, N P.

Affiliation

Freidinger RM; Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.

J Med Chem ; 33(7): 1843-5, 1990 Jul.

Article in En | MEDLINE | ID: mdl-2163451

Subject(s)

Oxytocin/antagonists & inhibitors; Peptides, Cyclic/chemical synthesis; Receptors, Angiotensin/drug effects; Receptors, Vasopressin; Amino Acid Sequence; Animals; Arginine Vasopressin/metabolism; Cell Membrane/metabolism; Female; Indicators and Reagents; Kidney/metabolism; Liver/metabolism; Molecular Sequence Data; Molecular Structure; Oxytocin/metabolism; Peptides, Cyclic/pharmacology; Rats; Receptors, Angiotensin/metabolism; Receptors, Oxytocin; Solubility; Structure-Activity Relationship; Uterus/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Oxytocin / Receptors, Angiotensin / Receptors, Vasopressin Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1990 Type: Article

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