SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

Hart, S; Goh, K C; Novotny-Diermayr, V; Hu, C Y; Hentze, H; Tan, Y C; Madan, B; Amalini, C; Loh, Y K; Ong, L C; William, A D; Lee, A; Poulsen, A; Jayaraman, R; Ong, K H; Ethirajulu, K; Dymock, B W; Wood, J W

Hart, S; Goh, K C; Novotny-Diermayr, V; Hu, C Y; Hentze, H; Tan, Y C; Madan, B; Amalini, C; Loh, Y K; Ong, L C; William, A D; Lee, A; Poulsen, A; Jayaraman, R; Ong, K H; Ethirajulu, K; Dymock, B W; Wood, J W.

Affiliation

Hart S; S*BIO Pte Ltd, Singapore, Singapore. stefan_hart@sbio.com

Leukemia ; 25(11): 1751-9, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21691275

Subject(s)

Antineoplastic Agents/therapeutic use; Bridged-Ring Compounds/therapeutic use; Janus Kinase 2/antagonists & inhibitors; Leukemia, Lymphoid/drug therapy; Leukemia, Myeloid/drug therapy; Pyrimidines/therapeutic use; Antineoplastic Agents/pharmacology; Blotting, Western; Bridged-Ring Compounds/pharmacology; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Flow Cytometry; Humans; Pyrimidines/pharmacology; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Bridged-Ring Compounds / Leukemia, Lymphoid / Leukemia, Myeloid / Janus Kinase 2 / Antineoplastic Agents Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2011 Type: Article Affiliation country: Singapore

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