Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of ß-synuclein as a potential CHK physiological substrate.

Ia, Kim K; Jeschke, Grace R; Deng, Yang; Kamaruddin, Mohd Aizuddin; Williamson, Nicholas A; Scanlon, Denis B; Culvenor, Janetta G; Hossain, Mohammed Iqbal; Purcell, Anthony W; Liu, Sheng; Zhu, Hong-Jian; Catimel, Bruno; Turk, Benjamin E; Cheng, Heung-Chin

Ia, Kim K; Jeschke, Grace R; Deng, Yang; Kamaruddin, Mohd Aizuddin; Williamson, Nicholas A; Scanlon, Denis B; Culvenor, Janetta G; Hossain, Mohammed Iqbal; Purcell, Anthony W; Liu, Sheng; Zhu, Hong-Jian; Catimel, Bruno; Turk, Benjamin E; Cheng, Heung-Chin.

Affiliation

Ia KK; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

Biochemistry ; 50(31): 6667-77, 2011 Aug 09.

Article in En | MEDLINE | ID: mdl-21699177

Subject(s)

Protein-Tyrosine Kinases/chemistry; Structural Homology, Protein; beta-Synuclein/chemistry; src Homology Domains; Amino Acid Motifs; Amino Acid Sequence; Animals; CSK Tyrosine-Protein Kinase; Catalytic Domain; Cytosol/enzymology; Cytosol/metabolism; HEK293 Cells; Humans; Molecular Sequence Data; Peptide Library; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Rats; Substrate Specificity; beta-Synuclein/metabolism; src-Family Kinases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Src Homology Domains / Structural Homology, Protein / Beta-Synuclein Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2011 Type: Article Affiliation country: Australia

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