Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/ß-catenin signaling.

Cimmino, Flora; Scoppettuolo, Maria Nunzia; Carotenuto, Marianeve; De Antonellis, Pasqualino; Dato, Valeria Di; De Vita, Gennaro; Zollo, Massimo

Cimmino, Flora; Scoppettuolo, Maria Nunzia; Carotenuto, Marianeve; De Antonellis, Pasqualino; Dato, Valeria Di; De Vita, Gennaro; Zollo, Massimo.

Affiliation

Cimmino F; CEINGE, Centro di Ingegneria Genetica, Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy.

J Neurooncol ; 106(1): 59-70, 2012 Jan.

Article in En | MEDLINE | ID: mdl-21735115

Subject(s)

Antineoplastic Agents/pharmacology; Brain Neoplasms/drug therapy; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Medulloblastoma/drug therapy; Wnt Proteins/physiology; beta Catenin/physiology; Animals; Apoptosis/physiology; Blood-Brain Barrier/physiology; Brain Neoplasms/pathology; Cell Cycle/physiology; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Flow Cytometry; Fluorescent Antibody Technique; G2 Phase/drug effects; Genes, Reporter; Indicators and Reagents; Luciferases/genetics; Medulloblastoma/pathology; Mice; Mice, SCID; Neoplasm Transplantation/physiology; Polymerase Chain Reaction; Protein Transport/physiology; Signal Transduction/physiology; Wnt Proteins/antagonists & inhibitors; beta Catenin/antagonists & inhibitors

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Bridged Bicyclo Compounds, Heterocyclic / Wnt Proteins / Beta Catenin / Medulloblastoma / Antineoplastic Agents Limits: Animals Language: En Journal: J Neurooncol Year: 2012 Type: Article Affiliation country: Italy

Fulltext

XML

PubMed Links

Search on Google