Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells.

Sun, Wen; Ding, Jin; Wu, Kun; Ning, Bei-Fang; Wen, Wen; Sun, Han-Yong; Han, Tao; Huang, Lei; Dong, Li-Wei; Yang, Wen; Deng, Xing; Li, Zhong; Wu, Meng-Chao; Feng, Gen-Sheng; Xie, Wei-Fen; Wang, Hong-Yang

Sun, Wen; Ding, Jin; Wu, Kun; Ning, Bei-Fang; Wen, Wen; Sun, Han-Yong; Han, Tao; Huang, Lei; Dong, Li-Wei; Yang, Wen; Deng, Xing; Li, Zhong; Wu, Meng-Chao; Feng, Gen-Sheng; Xie, Wei-Fen; Wang, Hong-Yang.

Affiliation

Sun W; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

Hepatology ; 54(4): 1259-72, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21735473

Subject(s)

Cell Differentiation/physiology; Hepatocyte Nuclear Factor 4/metabolism; Hepatocytes/metabolism; Liver Neoplasms, Experimental/pathology; Liver Neoplasms/pathology; Proteasome Endopeptidase Complex/metabolism; Proto-Oncogene Proteins/metabolism; Animals; Cell Differentiation/genetics; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Neoplastic; Hepatocyte Nuclear Factor 4/genetics; Hepatocytes/cytology; Humans; Proteasome Endopeptidase Complex/genetics; Proto-Oncogene Proteins/genetics; Random Allocation; Rats; Rats, Wistar; Stem Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Proto-Oncogene Proteins / Hepatocytes / Proteasome Endopeptidase Complex / Hepatocyte Nuclear Factor 4 / Liver Neoplasms / Liver Neoplasms, Experimental Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Hepatology Year: 2011 Type: Article Affiliation country: China

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