Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism.

Stefan, Mihaela; Jacobson, Eric M; Huber, Amanda K; Greenberg, David A; Li, Cheuk Wun; Skrabanek, Luce; Conception, Erlinda; Fadlalla, Mohammed; Ho, Kenneth; Tomer, Yaron

Stefan, Mihaela; Jacobson, Eric M; Huber, Amanda K; Greenberg, David A; Li, Cheuk Wun; Skrabanek, Luce; Conception, Erlinda; Fadlalla, Mohammed; Ho, Kenneth; Tomer, Yaron.

Affiliation

Stefan M; Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA. mihaela.stefan@mssm.edu

J Biol Chem ; 286(36): 31168-79, 2011 Sep 09.

Article in En | MEDLINE | ID: mdl-21757724

Subject(s)

Autoimmunity/genetics; Epigenesis, Genetic; Interferon-alpha/genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Thyroglobulin/genetics; Thyroid Diseases/genetics; Binding Sites; Case-Control Studies; Cell Line; Humans; Interferon Regulatory Factor-1/genetics; Interferon Regulatory Factor-1/metabolism; Thyroid Diseases/immunology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroglobulin / Thyroid Diseases / Autoimmunity / Promoter Regions, Genetic / Interferon-alpha / Polymorphism, Single Nucleotide / Epigenesis, Genetic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google