Monoclonal antibody blockade of IL-2 receptor &#945; during lymphopenia selectively depletes regulatory T cells in mice and humans.

Mitchell, Duane A; Cui, Xiuyu; Schmittling, Robert J; Sanchez-Perez, Luis; Snyder, David J; Congdon, Kendra L; Archer, Gary E; Desjardins, Annick; Friedman, Allan H; Friedman, Henry S; Herndon, James E; McLendon, Roger E; Reardon, David A; Vredenburgh, James J; Bigner, Darell D; Sampson, John H

Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.

Mitchell, Duane A; Cui, Xiuyu; Schmittling, Robert J; Sanchez-Perez, Luis; Snyder, David J; Congdon, Kendra L; Archer, Gary E; Desjardins, Annick; Friedman, Allan H; Friedman, Henry S; Herndon, James E; McLendon, Roger E; Reardon, David A; Vredenburgh, James J; Bigner, Darell D; Sampson, John H.

Affiliation

Mitchell DA; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.

Blood ; 118(11): 3003-12, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21768296

Subject(s)

Antibodies, Monoclonal/pharmacology; Interleukin-2 Receptor alpha Subunit/antagonists & inhibitors; Lymphocyte Depletion/methods; Lymphopenia/immunology; T-Lymphocytes, Regulatory/drug effects; Adult; Animals; Antibodies, Monoclonal/therapeutic use; Antibodies, Monoclonal, Humanized/pharmacology; Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Agents, Alkylating/therapeutic use; Brain Neoplasms/immunology; Brain Neoplasms/therapy; Cancer Vaccines/therapeutic use; Cells, Cultured; Combined Modality Therapy; Dacarbazine/analogs & derivatives; Dacarbazine/therapeutic use; Daclizumab; Drug Evaluation, Preclinical; Glioblastoma/immunology; Glioblastoma/therapy; Humans; Immunoglobulin G/pharmacology; Immunoglobulin G/therapeutic use; Immunotherapy/methods; Interleukin-2 Receptor alpha Subunit/immunology; Lymphopenia/pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Substrate Specificity/drug effects; Substrate Specificity/immunology; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/immunology; Temozolomide; Young Adult

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Depletion / T-Lymphocytes, Regulatory / Interleukin-2 Receptor alpha Subunit / Lymphopenia / Antibodies, Monoclonal Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google