Tolvaptan inhibits ERK-dependent cell proliferation, Clâ» secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.

Reif, Gail A; Yamaguchi, Tamio; Nivens, Emily; Fujiki, Hiroyuki; Pinto, Cibele S; Wallace, Darren P

Tolvaptan inhibits ERK-dependent cell proliferation, Clâ» secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.

Reif, Gail A; Yamaguchi, Tamio; Nivens, Emily; Fujiki, Hiroyuki; Pinto, Cibele S; Wallace, Darren P.

Affiliation

Reif GA; Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160-3018, USA.

Am J Physiol Renal Physiol ; 301(5): F1005-13, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21816754

Subject(s)

Antidiuretic Hormone Receptor Antagonists; Benzazepines/pharmacology; Cell Proliferation/drug effects; Chlorides/metabolism; Cysts/pathology; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Polycystic Kidney, Autosomal Dominant/metabolism; Renal Agents/pharmacology; Vasopressins/pharmacology; Adult; Aged; Amiloride/analogs & derivatives; Amiloride/pharmacology; Blotting, Western; Cells, Cultured; Cyclic AMP/biosynthesis; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Diuretics/pharmacology; Female; Humans; Male; Middle Aged; Tolvaptan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Agents / Benzazepines / Vasopressins / Chlorides / Polycystic Kidney, Autosomal Dominant / Cysts / Extracellular Signal-Regulated MAP Kinases / Cell Proliferation / Antidiuretic Hormone Receptor Antagonists Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2011 Type: Article Affiliation country: United States

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