Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.

Lusher, Scott J; Raaijmakers, Hans C A; Vu-Pham, Diep; Dechering, Koen; Lam, Tsang Wai; Brown, Angus R; Hamilton, Niall M; Nimz, Olaf; Bosch, Rolien; McGuire, Ross; Oubrie, Arthur; de Vlieg, Jacob

Lusher, Scott J; Raaijmakers, Hans C A; Vu-Pham, Diep; Dechering, Koen; Lam, Tsang Wai; Brown, Angus R; Hamilton, Niall M; Nimz, Olaf; Bosch, Rolien; McGuire, Ross; Oubrie, Arthur; de Vlieg, Jacob.

Affiliation

Lusher SJ; Department of Molecular Design and Informatics, DMPK, MSD, PO Box 20, 5340 BH Oss, The Netherlands. scott.lusher@merck.com

J Biol Chem ; 286(40): 35079-86, 2011 Oct 07.

Article in En | MEDLINE | ID: mdl-21849509

Subject(s)

Receptors, Progesterone/agonists; Receptors, Progesterone/antagonists & inhibitors; Receptors, Progesterone/metabolism; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray/methods; Dimerization; Drug Design; Drug Evaluation, Preclinical; Ligands; Mifepristone/chemistry; Models, Molecular; Molecular Conformation; Norethindrone/chemistry; Progesterone/chemistry; Protein Binding; Protein Conformation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Progesterone Limits: Animals Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: Netherlands

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