Matrix metalloproteinase-8 is overexpressed in Waldenström's macroglobulinemia cells, and specific inhibition of this metalloproteinase blocks release of soluble CD27.

Zhou, Yangsheng; Liu, Xia; Xu, Lian; Tseng, Hsiuyi; Cao, Yang; Jiang, Jingrui; Ciccarelli, Bryan T; Yang, Guang; Patterson, Christopher J; Hunter, Zachary R; Treon, Steven P

Zhou, Yangsheng; Liu, Xia; Xu, Lian; Tseng, Hsiuyi; Cao, Yang; Jiang, Jingrui; Ciccarelli, Bryan T; Yang, Guang; Patterson, Christopher J; Hunter, Zachary R; Treon, Steven P.

Affiliation

Zhou Y; Bing Center for Waldenström's Macroglobulinemia, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA.

Clin Lymphoma Myeloma Leuk ; 11(1): 172-5, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21856553

Subject(s)

Enzyme Inhibitors/pharmacology; Matrix Metalloproteinase 8/genetics; Matrix Metalloproteinase Inhibitors; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism; Waldenstrom Macroglobulinemia/enzymology; Waldenstrom Macroglobulinemia/genetics; Antigens, CD19/metabolism; Bone Marrow Cells/metabolism; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Humans; Matrix Metalloproteinase 9/genetics; Transfection; Tumor Necrosis Factor Receptor Superfamily, Member 7/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Waldenstrom Macroglobulinemia / Tumor Necrosis Factor Receptor Superfamily, Member 7 / Matrix Metalloproteinase 8 / Enzyme Inhibitors / Matrix Metalloproteinase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Lymphoma Myeloma Leuk Journal subject: NEOPLASIAS Year: 2011 Type: Article Affiliation country: United States

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