Chronic myeloid leukemia patients in prolonged remission following interferon-&#945; monotherapy have distinct cytokine and oligoclonal lymphocyte profile.

Kreutzman, Anna; Rohon, Peter; Faber, Edgar; Indrak, Karel; Juvonen, Vesa; Kairisto, Veli; Voglová, Jaroslava; Sinisalo, Marjatta; Flochová, Emília; Vakkila, Jukka; Arstila, Petteri; Porkka, Kimmo; Mustjoki, Satu

Chronic myeloid leukemia patients in prolonged remission following interferon-α monotherapy have distinct cytokine and oligoclonal lymphocyte profile.

Kreutzman, Anna; Rohon, Peter; Faber, Edgar; Indrak, Karel; Juvonen, Vesa; Kairisto, Veli; Voglová, Jaroslava; Sinisalo, Marjatta; Flochová, Emília; Vakkila, Jukka; Arstila, Petteri; Porkka, Kimmo; Mustjoki, Satu.

Affiliation

Kreutzman A; Hematology Research Unit, Biomedicum Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

PLoS One ; 6(8): e23022, 2011.

Article in En | MEDLINE | ID: mdl-21857985

Subject(s)

Cytokines/metabolism; Interferon-alpha/therapeutic use; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Lymphocytes/drug effects; Receptors, Antigen, T-Cell, gamma-delta/metabolism; Adult; Amino Acid Sequence; Base Sequence; CD3 Complex/metabolism; Female; Flow Cytometry; Gene Rearrangement, T-Lymphocyte/genetics; Humans; Immunologic Factors/therapeutic use; Immunophenotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Leukocyte Common Antigens/metabolism; Lymphocytes/immunology; Lymphocytes/metabolism; Male; Middle Aged; Molecular Sequence Data; Real-Time Polymerase Chain Reaction; Receptors, Antigen, T-Cell, gamma-delta/genetics; Remission Induction; Time Factors; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Cytokines / Receptors, Antigen, T-Cell, gamma-delta / Interferon-alpha Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Type: Article Affiliation country: Finland

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