AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Sykes, Stephen M; Lane, Steven W; Bullinger, Lars; Kalaitzidis, Demetrios; Yusuf, Rushdia; Saez, Borja; Ferraro, Francesca; Mercier, Francois; Singh, Harshabad; Brumme, Kristina M; Acharya, Sanket S; Scholl, Claudia; Schöll, Claudia; Tothova, Zuzana; Attar, Eyal C; Fröhling, Stefan; DePinho, Ronald A; Armstrong, Scott A; Gilliland, D Gary; Scadden, David T

Sykes, Stephen M; Lane, Steven W; Bullinger, Lars; Kalaitzidis, Demetrios; Yusuf, Rushdia; Saez, Borja; Ferraro, Francesca; Mercier, Francois; Singh, Harshabad; Brumme, Kristina M; Acharya, Sanket S; Scholl, Claudia; Schöll, Claudia; Tothova, Zuzana; Attar, Eyal C; Fröhling, Stefan; DePinho, Ronald A; Armstrong, Scott A; Gilliland, D Gary; Scadden, David T.

Affiliation

Sykes SM; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.

Cell ; 146(5): 697-708, 2011 Sep 02.

Article in En | MEDLINE | ID: mdl-21884932

Subject(s)

Forkhead Transcription Factors/metabolism; Leukemia, Myeloid/metabolism; Leukemia, Myeloid/pathology; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Animals; Antigens, CD34/metabolism; Apoptosis; Bone Marrow Cells/cytology; Bone Marrow Cells/metabolism; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Forkhead Box Protein O3; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Mice; Neoplastic Stem Cells/cytology; Neoplastic Stem Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Leukemia, Myeloid / Proto-Oncogene Proteins c-akt / Forkhead Transcription Factors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Year: 2011 Type: Article Affiliation country: United States

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