Role of lipid peroxidation and PPAR-Î´ in amplifying glucose-stimulated insulin secretion.

Cohen, Guy; Riahi, Yael; Shamni, Ofer; Guichardant, Michel; Chatgilialoglu, Chryssostomos; Ferreri, Carla; Kaiser, Nurit; Sasson, Shlomo

Cohen, Guy; Riahi, Yael; Shamni, Ofer; Guichardant, Michel; Chatgilialoglu, Chryssostomos; Ferreri, Carla; Kaiser, Nurit; Sasson, Shlomo.

Affiliation

Cohen G; Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute for Drug Research, Hebrew University, Jerusalem, Israel.

Diabetes ; 60(11): 2830-42, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21896929

Subject(s)

Hyperglycemia/metabolism; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Lipid Peroxidation; PPAR delta/metabolism; Signal Transduction; Aldehydes/adverse effects; Aldehydes/blood; Aldehydes/metabolism; Aldehydes/pharmacology; Animals; Cell Line; Diabetes Mellitus, Type 2/blood; Fatty Acids, Unsaturated/metabolism; Gene Silencing; Gerbillinae; Group IV Phospholipases A2/metabolism; Humans; Insulin Secretion; Insulin-Secreting Cells/drug effects; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Lipid Peroxidation/drug effects; Male; PPAR delta/agonists; PPAR delta/antagonists & inhibitors; PPAR delta/genetics; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism; Recombinant Proteins/agonists; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/metabolism; Tissue Culture Techniques

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Peroxidation / Signal Transduction / PPAR delta / Insulin-Secreting Cells / Hyperglycemia / Insulin Limits: Animals / Humans / Male Language: En Journal: Diabetes Year: 2011 Type: Article Affiliation country: Israel

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