p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.

Davies, Carwyn; Hogarth, Linda A; Dietrich, Philipp A; Bachmann, Petra S; Mackenzie, Karen L; Hall, Andrew G; Lock, Richard B

Davies, Carwyn; Hogarth, Linda A; Dietrich, Philipp A; Bachmann, Petra S; Mackenzie, Karen L; Hall, Andrew G; Lock, Richard B.

Affiliation

Davies C; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.

J Biol Chem ; 286(43): 37639-50, 2011 Oct 28.

Article in En | MEDLINE | ID: mdl-21903579

Subject(s)

Cyclin-Dependent Kinase Inhibitor p21/metabolism; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Tumor Suppressor Protein p53/metabolism; Acetylation/drug effects; Adolescent; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Apoptosis/drug effects; Apoptosis/genetics; Child; Child, Preschool; CpG Islands/genetics; Cyclin-Dependent Kinase Inhibitor p21/genetics; DNA Damage/drug effects; DNA Damage/genetics; DNA Methylation/drug effects; DNA Methylation/genetics; Etoposide/pharmacology; Female; Gene Expression Profiling; Histone Deacetylase Inhibitors/pharmacology; Histones/genetics; Histones/metabolism; Humans; Hydroxamic Acids/pharmacology; Jurkat Cells; Male; Mice; Mice, SCID; Neoplasm Transplantation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics; Promoter Regions, Genetic/genetics; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous; Tumor Suppressor Protein p53/genetics; Vorinostat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Gene Expression Regulation, Leukemic / Tumor Suppressor Protein p53 / Epigenesis, Genetic / Cyclin-Dependent Kinase Inhibitor p21 / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic_studies Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: Australia

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