The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia.

Drost, Adriana C; Seitz, Gabriele; Boehmler, Andreas; Funk, Mirjam; Norz, Karoline Pia; Zipfel, Anne; Xue, Xingkui; Kanz, Lothar; Möhle, Robert

Drost, Adriana C; Seitz, Gabriele; Boehmler, Andreas; Funk, Mirjam; Norz, Karoline Pia; Zipfel, Anne; Xue, Xingkui; Kanz, Lothar; Möhle, Robert.

Affiliation

Drost AC; Department of Hematology, Oncology, Rheumatology, Clinical Immunology and Pulmology, University Hospital Tübingen, Tübingen, Germany. adriana.drost@med.uni-tuebingen.de

Leuk Lymphoma ; 53(4): 665-73, 2012 Apr.

Article in En | MEDLINE | ID: mdl-21936770

Subject(s)

Leukotriene Antagonists/pharmacology; Leukotriene D4/pharmacology; Receptors, Leukotriene/genetics; Acetophenones/pharmacology; Actins/metabolism; Aged; Apoptosis/drug effects; Blotting, Western; Calcium/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Chemokines/pharmacology; Chemotaxis/drug effects; Cysteine/pharmacology; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Jurkat Cells; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Leukotrienes/pharmacology; Male; Mitogen-Activated Protein Kinases/metabolism; Phosphorylation/drug effects; Propionates/pharmacology; Quinolines/pharmacology; Receptors, Leukotriene/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles/pharmacology; Time Factors; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Leukotriene / Leukotriene D4 / Leukotriene Antagonists Limits: Aged / Female / Humans / Male Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2012 Type: Article Affiliation country: Germany

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