Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.

Kim, Kyung-Hee; Maderna, Andreas; Schnute, Mark E; Hegen, Martin; Mohan, Shashi; Miyashiro, Joy; Lin, Laura; Li, Evelyn; Keegan, Sean; Lussier, Jennifer; Wrocklage, Christopher; Nickerson-Nutter, Cheryl L; Wittwer, Arthur J; Soutter, Holly; Caspers, Nicole; Han, Seungil; Kurumbail, Ravi; Dunussi-Joannopoulos, Kyri; Douhan, John; Wissner, Allan

Kim, Kyung-Hee; Maderna, Andreas; Schnute, Mark E; Hegen, Martin; Mohan, Shashi; Miyashiro, Joy; Lin, Laura; Li, Evelyn; Keegan, Sean; Lussier, Jennifer; Wrocklage, Christopher; Nickerson-Nutter, Cheryl L; Wittwer, Arthur J; Soutter, Holly; Caspers, Nicole; Han, Seungil; Kurumbail, Ravi; Dunussi-Joannopoulos, Kyri; Douhan, John; Wissner, Allan.

Affiliation

Kim KH; Medicinal Chemistry, Pfizer, 200 Cambridge Park Drive, Cambridge, MA 02140, United States. khkim87@hotmail.com

Bioorg Med Chem Lett ; 21(21): 6258-63, 2011 Nov 01.

Article in En | MEDLINE | ID: mdl-21958547

Subject(s)

Arthritis, Rheumatoid/drug therapy; Protein Kinase Inhibitors/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Quinoxalines/pharmacology; Agammaglobulinaemia Tyrosine Kinase; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/therapeutic use; Quinoxalines/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Quinoxalines / Protein-Tyrosine Kinases / Protein Kinase Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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