Gefitinib resistance in HCC mahlavu cells: upregulation of CD133 expression, activation of IGF-1R signaling pathway, and enhancement of IGF-1R nuclear translocation.

Bodzin, Adam S; Wei, Zhengyu; Hurtt, Reginald; Gu, Tina; Doria, Cataldo

Bodzin, Adam S; Wei, Zhengyu; Hurtt, Reginald; Gu, Tina; Doria, Cataldo.

Affiliation

Bodzin AS; Division of Transplantation, Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.

J Cell Physiol ; 227(7): 2947-52, 2012 Jul.

Article in En | MEDLINE | ID: mdl-21959795

Subject(s)

Antigens, CD/genetics; Carcinoma, Hepatocellular/drug therapy; Cell Nucleus/metabolism; Glycoproteins/genetics; Liver Neoplasms/drug therapy; Peptides/genetics; Quinazolines/pharmacology; Receptor, IGF Type 1/metabolism; AC133 Antigen; Active Transport, Cell Nucleus/drug effects; Antigens, CD/metabolism; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/metabolism; Cell Line, Tumor; Cell Nucleus/drug effects; Cell Nucleus/genetics; Drug Resistance, Neoplasm; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/metabolism; Gefitinib; Glycoproteins/metabolism; Humans; Liver Neoplasms/genetics; Liver Neoplasms/metabolism; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/metabolism; Peptides/metabolism; Phosphorylation/drug effects; Protein Transport/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Receptor, IGF Type 1/genetics; Signal Transduction/drug effects; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Quinazolines / Glycoproteins / Antigens, CD / Cell Nucleus / Receptor, IGF Type 1 / Carcinoma, Hepatocellular / Liver Neoplasms Limits: Humans Language: En Journal: J Cell Physiol Year: 2012 Type: Article Affiliation country: United States

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