Down-regulated HS6ST2 in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes.

Wang, Wei; Zhong, Bo; Sun, Jian; Cao, Junling; Tian, Juan; Zhong, Nannan; Zhao, Wenxiang; Tian, Lifang; Xu, Peng; Guo, Dawei; Ju, Xichi; Ma, Wei; Li, Meng; Hou, Weikun; Lu, Shemin

Wang, Wei; Zhong, Bo; Sun, Jian; Cao, Junling; Tian, Juan; Zhong, Nannan; Zhao, Wenxiang; Tian, Lifang; Xu, Peng; Guo, Dawei; Ju, Xichi; Ma, Wei; Li, Meng; Hou, Weikun; Lu, Shemin.

Affiliation

Wang W; Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, People's Republic of China.

Rheumatology (Oxford) ; 50(12): 2176-86, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21972422

Subject(s)

Aggrecans/metabolism; Chondrocytes/metabolism; Kashin-Beck Disease/genetics; Osteoarthritis/genetics; Sulfotransferases/genetics; ADAM Proteins/metabolism; Adult; Aged; Analysis of Variance; Cartilage, Articular/metabolism; Cell Line; Cell Survival/physiology; DNA, Complementary/metabolism; Down-Regulation; Female; Gene Expression; Humans; Male; Matrix Metalloproteinase 3/metabolism; Middle Aged; Phenotype; RNA, Messenger/metabolism; RNA, Small Interfering/pharmacology; SOX9 Transcription Factor/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Sulfotransferases / Chondrocytes / Aggrecans / Kashin-Beck Disease Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2011 Type: Article

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