A CD8&#945;(-)  subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.

Vargas-Inchaustegui, Diego A; Demberg, Thorsten; Robert-Guroff, Marjorie

A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.

Vargas-Inchaustegui, Diego A; Demberg, Thorsten; Robert-Guroff, Marjorie.

Affiliation

Vargas-Inchaustegui DA; Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-5065, USA.

Immunology ; 134(3): 326-40, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21978002

Subject(s)

Antibody-Dependent Cell Cytotoxicity/immunology; CD8 Antigens/immunology; Cytotoxicity, Immunologic/immunology; Killer Cells, Natural/immunology; Animals; Antibody-Dependent Cell Cytotoxicity/drug effects; CD56 Antigen/immunology; CD56 Antigen/metabolism; CD8 Antigens/metabolism; Cells, Cultured; Cytotoxicity, Immunologic/drug effects; Flow Cytometry; Granzymes/genetics; Granzymes/immunology; Granzymes/metabolism; Interferon-gamma/genetics; Interferon-gamma/immunology; Interferon-gamma/metabolism; Interleukin-12/pharmacology; Interleukin-15/pharmacology; Killer Cells, Natural/metabolism; Leukocytes, Mononuclear/immunology; Leukocytes, Mononuclear/metabolism; Macaca mulatta; Membrane Glycoproteins/immunology; Perforin/genetics; Perforin/immunology; Perforin/metabolism; Receptors, IgG/immunology; Receptors, IgG/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Simian Acquired Immunodeficiency Syndrome/blood; Simian Acquired Immunodeficiency Syndrome/immunology; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/immunology; Tumor Necrosis Factor-alpha/metabolism; Viral Envelope Proteins/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / CD8 Antigens / Cytotoxicity, Immunologic / Antibody-Dependent Cell Cytotoxicity Type of study: Prognostic_studies Language: En Journal: Immunology Year: 2011 Type: Article Affiliation country: United States

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