Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Yoshino, Jun; Mills, Kathryn F; Yoon, Myeong Jin; Imai, Shin-ichiro

Yoshino, Jun; Mills, Kathryn F; Yoon, Myeong Jin; Imai, Shin-ichiro.

Affiliation

Yoshino J; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell Metab ; 14(4): 528-36, 2011 Oct 05.

Article in En | MEDLINE | ID: mdl-21982712

Subject(s)

Aging; Diabetes Mellitus, Type 2/physiopathology; Diet, High-Fat; NAD/biosynthesis; Nicotinamide Mononucleotide/pharmacology; Animals; Circadian Rhythm/genetics; Cytokines/metabolism; Diabetes Mellitus, Type 2/metabolism; Disease Models, Animal; Gene Expression Regulation; Glucose/metabolism; Hypoglycemic Agents/pharmacology; Insulin/metabolism; Lipid Metabolism; Mice; Nicotinamide Phosphoribosyltransferase/metabolism; Oxidative Stress/genetics; Sirtuin 1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Diabetes Mellitus, Type 2 / Diet, High-Fat / NAD / Nicotinamide Mononucleotide Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2011 Type: Article Affiliation country: United States

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