Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia.

Mirandola, Leonardo; Chiriva-Internati, Maurizio; Montagna, Daniela; Locatelli, Franco; Zecca, Marco; Ranzani, Marco; Basile, Andrea; Locati, Massimo; Cobos, Everardo; Kast, W Martin; Asselta, Rosanna; Paraboschi, Elvezia Maria; Comi, Paola; Chiaramonte, Raffaella

Mirandola, Leonardo; Chiriva-Internati, Maurizio; Montagna, Daniela; Locatelli, Franco; Zecca, Marco; Ranzani, Marco; Basile, Andrea; Locati, Massimo; Cobos, Everardo; Kast, W Martin; Asselta, Rosanna; Paraboschi, Elvezia Maria; Comi, Paola; Chiaramonte, Raffaella.

Affiliation

Mirandola L; Department of Medicine, Surgery and Dentistry, Università degli Studi di Milano, Milan, Italy.

J Pathol ; 226(5): 713-22, 2012 Apr.

Article in En | MEDLINE | ID: mdl-21984373

Subject(s)

Cell Proliferation; Chemotaxis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Receptor, Notch1/metabolism; Receptors, CCR5/metabolism; Receptors, CCR/metabolism; Signal Transduction; Adolescent; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Amyloid Precursor Protein Secretases/metabolism; Cell Proliferation/drug effects; Chemokines, CC/metabolism; Chemotaxis/drug effects; Child; Child, Preschool; Enzyme Inhibitors/pharmacology; Female; Gene Expression Regulation; Humans; Jurkat Cells; Male; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/immunology; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology; RNA Interference; RNA, Messenger/metabolism; Receptor, Notch1/genetics; Receptors, CCR/genetics; Receptors, CCR5/genetics; Receptors, CXCR4/metabolism; Signal Transduction/drug effects; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Chemotaxis / Receptors, CCR5 / Cell Proliferation / Receptor, Notch1 / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Receptors, CCR Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: J Pathol Year: 2012 Type: Article Affiliation country: Italy

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