Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway.

Furuya, Yoichi; Chan, Jennifer; Wan, En-Chi; Koskinen, Aulikki; Diener, Kerrilyn R; Hayball, John D; Regner, Matthias; Müllbacher, Arno; Alsharifi, Mohammed

Furuya, Yoichi; Chan, Jennifer; Wan, En-Chi; Koskinen, Aulikki; Diener, Kerrilyn R; Hayball, John D; Regner, Matthias; Müllbacher, Arno; Alsharifi, Mohammed.

Affiliation

Furuya Y; Department of Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

PLoS One ; 6(10): e25765, 2011.

Article in En | MEDLINE | ID: mdl-21998693

Subject(s)

Gamma Rays; Influenza A Virus, H1N1 Subtype/physiology; Influenza A Virus, H1N1 Subtype/radiation effects; Influenza A Virus, H3N2 Subtype/physiology; Influenza A Virus, H3N2 Subtype/radiation effects; Interferon Type I/metabolism; Lymphocytes/virology; Animals; Cell Line; Cricetinae; Dogs; Female; Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Influenza A Virus, H1N1 Subtype/metabolism; Influenza A Virus, H3N2 Subtype/metabolism; Interferon Type I/biosynthesis; Lymphocytes/cytology; Lymphocytes/metabolism; Membrane Glycoproteins/metabolism; Mice; Myeloid Differentiation Factor 88/metabolism; Neuraminidase/metabolism; Signal Transduction; T-Lymphocytes, Cytotoxic/cytology; T-Lymphocytes, Cytotoxic/metabolism; T-Lymphocytes, Cytotoxic/virology; Toll-Like Receptor 7/metabolism; Virus Activation/radiation effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Interferon Type I / Influenza A Virus, H1N1 Subtype / Influenza A Virus, H3N2 Subtype / Gamma Rays Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Type: Article Affiliation country: Australia

Fulltext

XML

PubMed Links

Search on Google