Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCOâ»3 output.

Baghdasaryan, Anna; Claudel, Thierry; Gumhold, Judith; Silbert, Dagmar; Adorini, Luciano; Roda, Aldo; Vecchiotti, Stefania; Gonzalez, Frank J; Schoonjans, Kristina; Strazzabosco, Mario; Fickert, Peter; Trauner, Michael

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCOâ»3 output.

Baghdasaryan, Anna; Claudel, Thierry; Gumhold, Judith; Silbert, Dagmar; Adorini, Luciano; Roda, Aldo; Vecchiotti, Stefania; Gonzalez, Frank J; Schoonjans, Kristina; Strazzabosco, Mario; Fickert, Peter; Trauner, Michael.

Affiliation

Baghdasaryan A; Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Hepatology ; 54(4): 1303-12, 2011 Oct.

Article in En | MEDLINE | ID: mdl-22006858

Subject(s)

Adenosine Triphosphatases/metabolism; Anion Transport Proteins/metabolism; Biliary Tract Diseases/drug therapy; Cholic Acids/pharmacology; Liver Diseases/drug therapy; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B/metabolism; Analysis of Variance; Animals; Bile Acids and Salts/metabolism; Biliary Tract Diseases/prevention & control; Disease Models, Animal; Liver Diseases/prevention & control; Male; Mice; Mice, Inbred C57BL; Random Allocation; Receptors, G-Protein-Coupled/antagonists & inhibitors; Statistics, Nonparametric; ATP-Binding Cassette Sub-Family B Member 4

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biliary Tract Diseases / Cholic Acids / Adenosine Triphosphatases / Receptors, Cytoplasmic and Nuclear / Anion Transport Proteins / Liver Diseases Limits: Animals Language: En Journal: Hepatology Year: 2011 Type: Article Affiliation country: Austria

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