The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

Meerang, Mayura; Ritz, Danilo; Paliwal, Shreya; Garajova, Zuzana; Bosshard, Matthias; Mailand, Niels; Janscak, Pavel; Hübscher, Ulrich; Meyer, Hemmo; Ramadan, Kristijan

Meerang, Mayura; Ritz, Danilo; Paliwal, Shreya; Garajova, Zuzana; Bosshard, Matthias; Mailand, Niels; Janscak, Pavel; Hübscher, Ulrich; Meyer, Hemmo; Ramadan, Kristijan.

Affiliation

Meerang M; Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Winterthurerstrasse 260, 8057 Zürich, Switzerland.

Nat Cell Biol ; 13(11): 1376-82, 2011 Oct 23.

Article in En | MEDLINE | ID: mdl-22020440

Subject(s)

Adenosine Triphosphatases/metabolism; Cell Cycle Proteins/metabolism; Cell Nucleus/metabolism; DNA Breaks, Double-Stranded; DNA Repair; Protein Processing, Post-Translational; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphatases/genetics; BRCA1 Protein/metabolism; Cell Cycle Proteins/genetics; Cell Line, Tumor; Cell Nucleus/radiation effects; Cell Survival; DNA-Binding Proteins/metabolism; Dose-Response Relationship, Radiation; Genomic Instability; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Nuclear Proteins/metabolism; Protein Transport; Proteins/metabolism; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Suppressor p53-Binding Protein 1; Ubiquitin-Protein Ligases; Ubiquitination; Valosin Containing Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Nucleus / Protein Processing, Post-Translational / Adenosine Triphosphatases / Cell Cycle Proteins / DNA Repair / DNA Breaks, Double-Stranded Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Cell Biol Year: 2011 Type: Article Affiliation country: Switzerland

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