Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

Gomes, Ana P; Duarte, Filipe V; Nunes, Patricia; Hubbard, Basil P; Teodoro, João S; Varela, Ana T; Jones, John G; Sinclair, David A; Palmeira, Carlos M; Rolo, Anabela P

Gomes, Ana P; Duarte, Filipe V; Nunes, Patricia; Hubbard, Basil P; Teodoro, João S; Varela, Ana T; Jones, John G; Sinclair, David A; Palmeira, Carlos M; Rolo, Anabela P.

Affiliation

Gomes AP; Center for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra 3004-517 Coimbra, Portugal.

Biochim Biophys Acta ; 1822(2): 185-95, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22027215

Subject(s)

Berberine/pharmacology; Diet, High-Fat; Mitochondria, Muscle/drug effects; Mitochondria/drug effects; Organelle Biogenesis; Sirtuin 1/metabolism; AMP-Activated Protein Kinases/metabolism; Animals; Cell Line; Glucose/metabolism; Hormones/metabolism; Hyperglycemia/metabolism; Insulin Resistance; Male; Mice; Mitochondria/metabolism; Mitochondria, Muscle/metabolism; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Myoblasts/drug effects; Myoblasts/metabolism; NAD/metabolism; Obesity/metabolism; Phosphorylation/drug effects; Rats; Rats, Sprague-Dawley; Sirtuin 1/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Berberine / Organelle Biogenesis / Sirtuin 1 / Diet, High-Fat / Mitochondria / Mitochondria, Muscle Limits: Animals Language: En Journal: Biochim Biophys Acta Year: 2012 Type: Article Affiliation country: Portugal

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