Hyperlipoproteinemia Type III/metabolism; Lipoproteins, LDL/metabolism; Matrix Metalloproteinase 9/metabolism; Monocytes/metabolism; Plaque, Atherosclerotic/metabolism; Vascular Calcification/metabolism; Animals; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Cells, Cultured; Dipeptides/pharmacology; Disease Models, Animal; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Humans; Hyperlipoproteinemia Type III/complications; Hyperlipoproteinemia Type III/pathology; Immunohistochemistry; Lipoproteins, LDL/pharmacology; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase Inhibitors; Mice; Mice, Knockout; Monocytes/cytology; Oxidation-Reduction; Plaque, Atherosclerotic/complications; Plaque, Atherosclerotic/pathology; Rheology; Stress, Mechanical; Tissue Inhibitor of Metalloproteinase-1/pharmacology; Vascular Calcification/complications; Vascular Calcification/pathology