The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.

Young, Lisa E; Moore, Ashleigh E; Sokol, Lena; Meisner-Kober, Nicole; Dixon, Dan A

Young, Lisa E; Moore, Ashleigh E; Sokol, Lena; Meisner-Kober, Nicole; Dixon, Dan A.

Affiliation

Young LE; Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA.

Mol Cancer Res ; 10(1): 167-80, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22049153

Subject(s)

Cyclooxygenase 2/genetics; ELAV Proteins/physiology; MicroRNAs/antagonists & inhibitors; Animals; Caco-2 Cells; Carcinoma/genetics; Carcinoma/metabolism; Carcinoma/pathology; Cells, Cultured; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Cyclooxygenase 2/metabolism; Down-Regulation/genetics; ELAV Proteins/genetics; ELAV Proteins/metabolism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HT29 Cells; HeLa Cells; Humans; Mice; Mice, Transgenic; MicroRNAs/genetics; MicroRNAs/metabolism; Protein Binding; Protein Transport/genetics; RNA Stability/genetics; Regulatory Sequences, Ribonucleic Acid/genetics; Regulatory Sequences, Ribonucleic Acid/physiology; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Cyclooxygenase 2 / ELAV Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Res Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2012 Type: Article Affiliation country: United States

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