Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A).

Restani, Laura; Antonucci, Flavia; Gianfranceschi, Laura; Rossi, Chiara; Rossetto, Ornella; Caleo, Matteo

Restani, Laura; Antonucci, Flavia; Gianfranceschi, Laura; Rossi, Chiara; Rossetto, Ornella; Caleo, Matteo.

Affiliation

Restani L; CNR Neuroscience Institute, 56100 Pisa, Italy.

J Neurosci ; 31(44): 15650-9, 2011 Nov 02.

Article in En | MEDLINE | ID: mdl-22049408

Subject(s)

Botulinum Toxins, Type A/pharmacology; Botulinum Toxins/pharmacokinetics; Nerve Tissue Proteins/metabolism; Neurotoxins/pharmacology; Transcytosis/drug effects; Visual Pathways/drug effects; Animals; Biological Transport/drug effects; Botulinum Toxins/administration & dosage; CD11b Antigen/metabolism; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists/toxicity; Functional Laterality/drug effects; Glial Fibrillary Acidic Protein/metabolism; Injections, Intraocular/methods; Kainic Acid/toxicity; Nerve Tissue Proteins/drug effects; Phosphopyruvate Hydratase/metabolism; Rats; Rats, Long-Evans; Superior Colliculi/drug effects; Superior Colliculi/metabolism; Synaptosomal-Associated Protein 25/drug effects; Synaptosomal-Associated Protein 25/metabolism; Time Factors; Vesicular Glutamate Transport Protein 1/metabolism; Vesicular Glutamate Transport Protein 2/metabolism; Visual Pathways/injuries; Visual Pathways/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Visual Pathways / Botulinum Toxins / Botulinum Toxins, Type A / Transcytosis / Nerve Tissue Proteins / Neurotoxins Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 2011 Type: Article Affiliation country: Italy

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