Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.

Kuzmanov, Aleksandar; Wielockx, Ben; Rezaei, Maryam; Kettelhake, Antje; Breier, Georg

Kuzmanov, Aleksandar; Wielockx, Ben; Rezaei, Maryam; Kettelhake, Antje; Breier, Georg.

Affiliation

Kuzmanov A; Department of Pathology, University of Technology Dresden, Germany.

Int J Cancer ; 131(5): E603-13, 2012 Sep 01.

Article in En | MEDLINE | ID: mdl-22095574

Subject(s)

Bone Neoplasms/blood supply; Bone Neoplasms/pathology; Cell Proliferation; Lymphokines/metabolism; Mixed Function Oxygenases/metabolism; Osteosarcoma/blood supply; Osteosarcoma/pathology; Platelet-Derived Growth Factor/metabolism; Angiogenesis Inducing Agents; Animals; Apoptosis; Blotting, Western; Bone Neoplasms/metabolism; Female; Hypoxia-Inducible Factor 1/genetics; Hypoxia-Inducible Factor 1/metabolism; Immunoenzyme Techniques; Lymphokines/antagonists & inhibitors; Lymphokines/genetics; Mice; Mice, Inbred C3H; Mixed Function Oxygenases/genetics; Neovascularization, Pathologic; Osteosarcoma/metabolism; Pericytes/metabolism; Pericytes/pathology; Platelet-Derived Growth Factor/antagonists & inhibitors; Platelet-Derived Growth Factor/genetics; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Receptor, Platelet-Derived Growth Factor alpha/genetics; Receptor, Platelet-Derived Growth Factor alpha/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Cells, Cultured

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Platelet-Derived Growth Factor / Osteosarcoma / Lymphokines / Cell Proliferation / Mixed Function Oxygenases Limits: Animals Language: En Journal: Int J Cancer Year: 2012 Type: Article Affiliation country: Germany

Fulltext

XML

PubMed Links

Search on Google