Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.

Chung, Suhman; Miller, Jennifer T; Johnson, Barry C; Hughes, Stephen H; Le Grice, Stuart F J

Chung, Suhman; Miller, Jennifer T; Johnson, Barry C; Hughes, Stephen H; Le Grice, Stuart F J.

Affiliation

Chung S; HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

J Biol Chem ; 287(6): 4066-75, 2012 Feb 03.

Article in En | MEDLINE | ID: mdl-22105069

Subject(s)

Enzyme Inhibitors/chemistry; HIV-1/enzymology; Ribonuclease H, Human Immunodeficiency Virus/antagonists & inhibitors; Ribonuclease H, Human Immunodeficiency Virus/chemistry; Thiophenes/chemistry; Amino Acid Substitution; Cell Line; Crystallography, X-Ray; HIV-1/genetics; Humans; Mutagenesis; Mutation, Missense; Protein Structure, Secondary; Protein Structure, Tertiary; Ribonuclease H, Human Immunodeficiency Virus/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / HIV-1 / Enzyme Inhibitors / Ribonuclease H, Human Immunodeficiency Virus Limits: Humans Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

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