RhoB mediates antitumor synergy of combined ixabepilone and sunitinib in human ovarian serous cancer.

Vishnu, Prakash; Colon-Otero, Gerardo; Kennedy, Gregory T; Marlow, Laura A; Kennedy, William P; Wu, Kevin J; Santoso, Joseph T; Copland, John A

Vishnu, Prakash; Colon-Otero, Gerardo; Kennedy, Gregory T; Marlow, Laura A; Kennedy, William P; Wu, Kevin J; Santoso, Joseph T; Copland, John A.

Affiliation

Vishnu P; Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.

Gynecol Oncol ; 124(3): 589-97, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22115851

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Cystadenocarcinoma, Serous/drug therapy; Cystadenocarcinoma, Serous/enzymology; Epothilones/pharmacology; Indoles/pharmacology; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/enzymology; Pyrroles/pharmacology; rhoB GTP-Binding Protein/metabolism; Carcinoma, Ovarian Epithelial; Cell Growth Processes/drug effects; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Epothilones/administration & dosage; Female; Humans; Indoles/administration & dosage; Neoplasms, Glandular and Epithelial/drug therapy; Neoplasms, Glandular and Epithelial/enzymology; Pyrroles/administration & dosage; Sunitinib; Up-Regulation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Pyrroles / Antineoplastic Combined Chemotherapy Protocols / Cystadenocarcinoma, Serous / RhoB GTP-Binding Protein / Epothilones / Indoles Limits: Female / Humans Language: En Journal: Gynecol Oncol Year: 2012 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google