Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia.

Leder, Kevin; Foo, Jasmine; Skaggs, Brian; Gorre, Mercedes; Sawyers, Charles L; Michor, Franziska

Leder, Kevin; Foo, Jasmine; Skaggs, Brian; Gorre, Mercedes; Sawyers, Charles L; Michor, Franziska.

Affiliation

Leder K; Program for Industrial and Systems Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.

PLoS One ; 6(11): e27682, 2011.

Article in En | MEDLINE | ID: mdl-22140458

Subject(s)

Drug Resistance, Neoplasm/genetics; Fusion Proteins, bcr-abl/chemistry; Fusion Proteins, bcr-abl/genetics; Genetic Fitness; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/enzymology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Mutation/genetics; Protein-Tyrosine Kinases/chemistry; Protein-Tyrosine Kinases/genetics; Cell Proliferation/drug effects; Drug Resistance, Neoplasm/drug effects; Genetic Fitness/drug effects; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Mutation Rate; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein Structure, Tertiary; Risk Factors; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Fusion Proteins, bcr-abl / Drug Resistance, Neoplasm / Genetic Fitness / Mutation Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Type: Article Affiliation country: United States

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