The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-Î³ and interleukin-17 production by human CD4+ T cells.

Maeshima, Keisuke; Yamaoka, Kunihiro; Kubo, Satoshi; Nakano, Kazuhisa; Iwata, Shigeru; Saito, Kazuyoshi; Ohishi, Masanobu; Miyahara, Hisaaki; Tanaka, Shinya; Ishii, Koji; Yoshimatsu, Hironobu; Tanaka, Yoshiya

Maeshima, Keisuke; Yamaoka, Kunihiro; Kubo, Satoshi; Nakano, Kazuhisa; Iwata, Shigeru; Saito, Kazuyoshi; Ohishi, Masanobu; Miyahara, Hisaaki; Tanaka, Shinya; Ishii, Koji; Yoshimatsu, Hironobu; Tanaka, Yoshiya.

Affiliation

Maeshima K; University of Occupational and Environmental Health, Japan.

Arthritis Rheum ; 64(6): 1790-8, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22147632

Subject(s)

CD4-Positive T-Lymphocytes/drug effects; Interferon-gamma/biosynthesis; Interleukin-17/biosynthesis; Janus Kinase 3/antagonists & inhibitors; Pyrimidines/pharmacology; Pyrroles/pharmacology; Synovial Membrane/drug effects; Synovitis/metabolism; Animals; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; Cartilage, Articular/drug effects; Cartilage, Articular/immunology; Cartilage, Articular/metabolism; Cell Proliferation/drug effects; Humans; Mice; Monocytes/drug effects; Monocytes/immunology; Monocytes/metabolism; Piperidines; Synovial Membrane/immunology; Synovial Membrane/metabolism; Synovitis/immunology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Synovial Membrane / Synovitis / CD4-Positive T-Lymphocytes / Interferon-gamma / Interleukin-17 / Janus Kinase 3 Limits: Animals / Humans Language: En Journal: Arthritis Rheum Year: 2012 Type: Article Affiliation country: Japan

Fulltext

XML

PubMed Links

Search on Google