NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages.

Ejlerskov, Patrick; Christensen, Dan Ploug; Beyaie, David; Burritt, James B; Paclet, Marie-Helene; Gorlach, Agnes; van Deurs, Bo; Vilhardt, Frederik

Ejlerskov, Patrick; Christensen, Dan Ploug; Beyaie, David; Burritt, James B; Paclet, Marie-Helene; Gorlach, Agnes; van Deurs, Bo; Vilhardt, Frederik.

Affiliation

Ejlerskov P; Department of Cellular and Molecular Medicine, Panum Institute, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2200N, Denmark.

J Biol Chem ; 287(7): 4835-52, 2012 Feb 10.

Article in En | MEDLINE | ID: mdl-22157766

Subject(s)

Clathrin-Coated Vesicles/enzymology; Macrophage Activation/physiology; Macrophages/enzymology; Membrane Glycoproteins/metabolism; NADPH Oxidases/metabolism; rab GTP-Binding Proteins/metabolism; Adenosine Triphosphate/genetics; Adenosine Triphosphate/metabolism; Animals; CD40 Ligand/genetics; CD40 Ligand/metabolism; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/metabolism; Cells, Cultured; Clathrin/genetics; Clathrin/metabolism; Clathrin-Coated Vesicles/genetics; Cytochrome b Group/genetics; Cytochrome b Group/metabolism; Endosomes/enzymology; Endosomes/genetics; Exocytosis/physiology; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Macrophages/cytology; Membrane Glycoproteins/genetics; Microglia/enzymology; NADPH Oxidase 2; NADPH Oxidases/genetics; Rats; Superoxides/metabolism; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; rab GTP-Binding Proteins/genetics; rab27 GTP-Binding Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / NADPH Oxidases / Rab GTP-Binding Proteins / Clathrin-Coated Vesicles / Macrophage Activation / Macrophages Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: Denmark

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