Multiple-dose safety, pharmacokinetics, and pharmacodynamics of the µ-opioid receptor inverse agonist GSK1521498.

Nathan, Pradeep J; Bush, Mark A; Tao, Wenli X; Koch, Annelize; Davies, Kirsty M; Maltby, Kay; O'Neill, Barry V; Napolitano, Antonella; Skeggs, Andrew L; Brooke, Allison C; Richards, Duncan B; Williams, Pauline M; Bullmore, Edward T

Nathan, Pradeep J; Bush, Mark A; Tao, Wenli X; Koch, Annelize; Davies, Kirsty M; Maltby, Kay; O'Neill, Barry V; Napolitano, Antonella; Skeggs, Andrew L; Brooke, Allison C; Richards, Duncan B; Williams, Pauline M; Bullmore, Edward T.

Affiliation

Nathan PJ; GlaxoSmithKline, Clinical Unit Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2GG UK. pradeep.j.nathan@gsk.com

J Clin Pharmacol ; 52(10): 1456-67, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22162534

Subject(s)

Indans/administration & dosage; Receptors, Opioid, mu/agonists; Triazoles/administration & dosage; Adult; Affect/drug effects; Cognition/drug effects; Double-Blind Method; Drug Administration Schedule; Female; Hot Temperature; Humans; Indans/adverse effects; Indans/pharmacokinetics; Male; Middle Aged; Pain Threshold/drug effects; Pressure; Triazoles/adverse effects; Triazoles/pharmacokinetics; Young Adult

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Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Receptors, Opioid, mu / Indans Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2012 Type: Article

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