Learning to live together: harnessing regulatory T cells to induce organ transplant tolerance.
Yale J Biol Med
; 84(4): 345-51, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-22180672
ABSTRACT
The discovery of immune cells with regulatory effects has created considerable excitement for their potential use in inducing tolerance to transplanted tissues. Despite the fact that these cells possess essential functions in vivo, attempts to translate them into effective clinical therapies has proved challenging due to a number of unanticipated complexities in their behavior. This article provides a broad summary of research done to understand the largest of the regulatory cell subtypes, namely CD4+Foxp3+ Regulatory T cells (T(Regs)). Special attention will be paid to current and future difficulties in using T(Regs) clinically, as well as room for improvement and innovation in this field.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes, Regulatory
/
Transplants
/
Graft Survival
/
Immune Tolerance
Limits:
Humans
Language:
En
Journal:
Yale J Biol Med
Year:
2011
Type:
Article
Affiliation country:
United States