Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.

Wu, Zhicai; Yang, Cangming; Xiong, Yusheng; Feng, Zhe; Lombardo, Matthew; Verras, Andreas; Chabin, Renee M; Xu, Suoyu; Tong, Xinchun; Xie, Dan; Lassman, Mike E; Bhatt, Urmi R; Garcia-Calvo, Margarita M; Geissler, Wayne; Shen, Zhu; Chen, Qing; Sinharoy, Ranabir; Hale, Jeffrey J; Tata, James R; Pinto, Shirly; Shen, Dong-Ming; Colletti, Steven L

Wu, Zhicai; Yang, Cangming; Xiong, Yusheng; Feng, Zhe; Lombardo, Matthew; Verras, Andreas; Chabin, Renee M; Xu, Suoyu; Tong, Xinchun; Xie, Dan; Lassman, Mike E; Bhatt, Urmi R; Garcia-Calvo, Margarita M; Geissler, Wayne; Shen, Zhu; Chen, Qing; Sinharoy, Ranabir; Hale, Jeffrey J; Tata, James R; Pinto, Shirly; Shen, Dong-Ming; Colletti, Steven L.

Affiliation

Wu Z; Department of Discovery Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. zhicai_wu@merck.com

Bioorg Med Chem Lett ; 22(4): 1774-8, 2012 Feb 15.

Article in En | MEDLINE | ID: mdl-22248857

Subject(s)

Alanine/chemistry; Carboxypeptidases/antagonists & inhibitors; Drug Discovery; Alanine/pharmacology; Animals; Enzyme Activation/drug effects; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carboxypeptidases / Alanine / Drug Discovery Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States

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