[IAPs: a central element in the NF-κB activating signaling pathway]. / Les IAP au cÅur de la signalisation NF-κB.
Med Sci (Paris)
; 28(1): 69-75, 2012 Jan.
Article
in Fr
| MEDLINE
| ID: mdl-22289833
ABSTRACT
The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Gene Expression Regulation
/
NF-kappa B
/
Inhibitor of Apoptosis Proteins
/
X-Linked Inhibitor of Apoptosis Protein
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Med Sci (Paris)
Journal subject:
MEDICINA
Year:
2012
Type:
Article
Affiliation country:
France