A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles.

Shaikh, Fyza Y; Cox, Reagan G; Lifland, Aaron W; Hotard, Anne L; Williams, John V; Moore, Martin L; Santangelo, Philip J; Crowe, James E

Shaikh, Fyza Y; Cox, Reagan G; Lifland, Aaron W; Hotard, Anne L; Williams, John V; Moore, Martin L; Santangelo, Philip J; Crowe, James E.

Affiliation

Shaikh FY; Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

mBio ; 3(1)2012.

Article in En | MEDLINE | ID: mdl-22318318

Subject(s)

Phenylalanine; Respiratory Syncytial Virus Infections/virology; Respiratory Syncytial Virus, Human/physiology; Viral Fusion Proteins/genetics; Virus Assembly; Amino Acid Sequence; Cell Line; Cell Membrane/metabolism; Cytoplasm/metabolism; Cytoskeleton/ultrastructure; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; RNA, Viral/genetics; RNA, Viral/metabolism; Recombinant Proteins; Respiratory Syncytial Virus, Human/genetics; Respiratory Syncytial Virus, Human/ultrastructure; Sequence Alignment; Viral Fusion Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylalanine / Viral Fusion Proteins / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections / Virus Assembly Limits: Humans Language: En Journal: MBio Year: 2012 Type: Article Affiliation country: United States

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