Atopic diseases in twins born after assisted reproduction.
Paediatr Perinat Epidemiol
; 26(2): 140-5, 2012 Mar.
Article
in En
| MEDLINE
| ID: mdl-22324500
ABSTRACT
We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma 0.95 [0.85, 1.07], P = 0.403; hay fever 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis 1.02 [0.81, 1.11], P = 0.773 respectively) compared with children born after spontaneous conception. Assisted reproduction did not modify the heritability of atopic diseases. This study does not support an association between assisted reproduction and development of atopic diseases. This result must be confirmed in subsequent studies, preferably of singleton populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Rhinitis, Allergic, Seasonal
/
Reproductive Techniques, Assisted
/
Dermatitis, Atopic
/
Diseases in Twins
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Paediatr Perinat Epidemiol
Journal subject:
EPIDEMIOLOGIA
/
PEDIATRIA
/
PERINATOLOGIA
Year:
2012
Type:
Article
Affiliation country:
Denmark