A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.

Davies, David J; Crowe, Matthew; Lucas, Nolwenn; Quinn, Joanna; Miller, David D; Pritchard, Sara; Grose, David; Bettini, Ezio; Calcinaghi, Novella; Virginio, Caterina; Abberley, Lee; Goldsmith, Paul; Michel, Anton D; Chessell, Iain P; Kew, James N C; Miller, Neil D; Gunthorpe, Martin J

Davies, David J; Crowe, Matthew; Lucas, Nolwenn; Quinn, Joanna; Miller, David D; Pritchard, Sara; Grose, David; Bettini, Ezio; Calcinaghi, Novella; Virginio, Caterina; Abberley, Lee; Goldsmith, Paul; Michel, Anton D; Chessell, Iain P; Kew, James N C; Miller, Neil D; Gunthorpe, Martin J.

Affiliation

Davies DJ; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

Bioorg Med Chem Lett ; 22(7): 2620-3, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-22366657

Subject(s)

Analgesics/chemical synthesis; Antidepressive Agents/chemical synthesis; Benzimidazoles/chemical synthesis; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Analgesics/pharmacology; Antidepressive Agents/pharmacology; Benzimidazoles/pharmacology; Drug Discovery; High-Throughput Screening Assays; Humans; Patch-Clamp Techniques; Radioligand Assay; Receptors, N-Methyl-D-Aspartate/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Receptors, N-Methyl-D-Aspartate / Analgesics / Antidepressive Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United kingdom

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