Lineage-specific virulence determinants of Haemophilus influenzae biogroup aegyptius.
Emerg Infect Dis
; 18(3): 449-57, 2012 Mar.
Article
in En
| MEDLINE
| ID: mdl-22377449
ABSTRACT
An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Haemophilus influenzae
/
Haemophilus Infections
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Emerg Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2012
Type:
Article
Affiliation country:
United kingdom