Dithiolethiones inhibit NF-&#954;B activity via covalent modification in human estrogen receptor-negative breast cancer.

Switzer, Christopher H; Cheng, Robert Y-S; Ridnour, Lisa A; Murray, Margaret C; Tazzari, Valerio; Sparatore, Anna; Del Soldato, Piero; Hines, Harry B; Glynn, Sharon A; Ambs, Stefan; Wink, David A

Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

Switzer, Christopher H; Cheng, Robert Y-S; Ridnour, Lisa A; Murray, Margaret C; Tazzari, Valerio; Sparatore, Anna; Del Soldato, Piero; Hines, Harry B; Glynn, Sharon A; Ambs, Stefan; Wink, David A.

Affiliation

Switzer CH; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

Cancer Res ; 72(9): 2394-404, 2012 May 01.

Article in En | MEDLINE | ID: mdl-22436383

Subject(s)

Antineoplastic Agents/pharmacology; Breast Neoplasms/drug therapy; NF-kappa B/antagonists & inhibitors; Thiones/pharmacology; Active Transport, Cell Nucleus; Adenocarcinoma/drug therapy; Adenocarcinoma/genetics; Adenocarcinoma/metabolism; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Cell Line, Tumor; Cell Nucleus/metabolism; Female; Humans; I-kappa B Kinase/metabolism; NF-kappa B/genetics; NF-kappa B/metabolism; Nitric Oxide Synthase Type II/biosynthesis; Receptors, Estrogen/biosynthesis; Transcriptional Activation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiones / Breast Neoplasms / NF-kappa B / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Cancer Res Year: 2012 Type: Article Affiliation country: United States

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