Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Manglik, Aashish; Kruse, Andrew C; Kobilka, Tong Sun; Thian, Foon Sun; Mathiesen, Jesper M; Sunahara, Roger K; Pardo, Leonardo; Weis, William I; Kobilka, Brian K; Granier, Sébastien

Manglik, Aashish; Kruse, Andrew C; Kobilka, Tong Sun; Thian, Foon Sun; Mathiesen, Jesper M; Sunahara, Roger K; Pardo, Leonardo; Weis, William I; Kobilka, Brian K; Granier, Sébastien.

Affiliation

Manglik A; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature ; 485(7398): 321-6, 2012 Mar 21.

Article in En | MEDLINE | ID: mdl-22437502

Subject(s)

Morphinans/chemistry; Receptors, Opioid, mu/antagonists & inhibitors; Receptors, Opioid, mu/chemistry; Animals; Binding Sites; Crystallography, X-Ray; Ligands; Mice; Models, Molecular; Morphinans/metabolism; Morphinans/pharmacology; Protein Conformation; Protein Multimerization; Receptors, Opioid, mu/metabolism; Solvents/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Opioid, mu / Morphinans Limits: Animals Language: En Journal: Nature Year: 2012 Type: Article Affiliation country: United States

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