Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice.

Balabanian, Karl; Brotin, Emilie; Biajoux, Vincent; Bouchet-Delbos, Laurence; Lainey, Elodie; Fenneteau, Odile; Bonnet, Dominique; Fiette, Laurence; Emilie, Dominique; Bachelerie, Françoise

Balabanian, Karl; Brotin, Emilie; Biajoux, Vincent; Bouchet-Delbos, Laurence; Lainey, Elodie; Fenneteau, Odile; Bonnet, Dominique; Fiette, Laurence; Emilie, Dominique; Bachelerie, Françoise.

Affiliation

Balabanian K; Inserm Unité Mixte de Recherche (UMR) S996, Université Paris-Sud, Laboratory of Excellence in Research on Medication and Innovative Therapeutics, Clamart, France. karl.balabanian@u-psud.fr

Blood ; 119(24): 5722-30, 2012 Jun 14.

Article in En | MEDLINE | ID: mdl-22438253

Subject(s)

Cell Compartmentation/immunology; Desensitization, Immunologic; Lymphocytes/immunology; Receptors, CXCR4/immunology; Animals; B-Lymphocytes/drug effects; B-Lymphocytes/pathology; Benzylamines; Bone Marrow/pathology; Chemokine CXCL12/pharmacology; Chemotaxis/drug effects; Chronic Disease; Cyclams; Heterocyclic Compounds/pharmacology; Homeostasis/drug effects; Humans; Lymph Nodes/drug effects; Lymph Nodes/pathology; Lymphocyte Count; Lymphocytes/drug effects; Mice; Mutation/genetics; Neutropenia/blood; Neutropenia/pathology; Signal Transduction/drug effects; T-Lymphocytes/drug effects; T-Lymphocytes/pathology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Cell Compartmentation / Desensitization, Immunologic / Receptors, CXCR4 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: France

Fulltext

XML

PubMed Links

Search on Google