A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.

Graham, Thomas H; Liu, Wensheng; Verras, Andreas; Reibarkh, Mikhail; Bleasby, Kelly; Bhatt, Urmi R; Chen, Qing; Garcia-Calvo, Margarita; Geissler, Wayne M; Gorski, Judith N; He, Huaibing; Lassman, Michael E; Lisnock, JeanMarie; Li, Xiaohua; Shen, Zhu; Tong, Xinchun; Tung, Elaine C; Wiltsie, Judyann; Xie, Dan; Xu, Suoyu; Xiao, Jianying; Hale, Jeffrey J; Pinto, Shirly; Shen, Dong-Ming

Graham, Thomas H; Liu, Wensheng; Verras, Andreas; Reibarkh, Mikhail; Bleasby, Kelly; Bhatt, Urmi R; Chen, Qing; Garcia-Calvo, Margarita; Geissler, Wayne M; Gorski, Judith N; He, Huaibing; Lassman, Michael E; Lisnock, JeanMarie; Li, Xiaohua; Shen, Zhu; Tong, Xinchun; Tung, Elaine C; Wiltsie, Judyann; Xie, Dan; Xu, Suoyu; Xiao, Jianying; Hale, Jeffrey J; Pinto, Shirly; Shen, Dong-Ming.

Affiliation

Graham TH; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. thomas.graham@merck.com

Bioorg Med Chem Lett ; 22(8): 2818-22, 2012 Apr 15.

Article in En | MEDLINE | ID: mdl-22444685

Subject(s)

Amines/pharmacology; Carboxypeptidases/antagonists & inhibitors; Cyclopentanes/pharmacology; Drug Discovery; Enzyme Inhibitors; Amines/chemical synthesis; Amines/chemistry; Animals; Cyclization; Cyclopentanes/chemical synthesis; Cyclopentanes/chemistry; Enzyme Activation/drug effects; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Inhibitory Concentration 50; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Obesity/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carboxypeptidases / Cyclopentanes / Enzyme Inhibitors / Drug Discovery / Amines Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States

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