The tangled web of non-canonical Wnt signalling in neural migration.
Neurosignals
; 20(3): 202-20, 2012.
Article
in En
| MEDLINE
| ID: mdl-22456117
In all multicellular animals, successful embryogenesis is dependent on the ability of cells to detect the status of the local environment and respond appropriately. The nature of the extracellular environment is communicated to the intracellular compartment by ligand/receptor interactions at the cell surface. The Wnt canonical and non-canonical signalling pathways are found in the most primitive metazoans, and they play an essential role in the most fundamental developmental processes in all multicellular organisms. Vertebrates have expanded the number of Wnts and Frizzled receptors and have additionally evolved novel Wnt receptor families (Ryk, Ror). The multiplicity of potential interactions between Wnts, their receptors and downstream effectors has exponentially increased the complexity of the signal transduction network. Signalling through each of the Wnt pathways, as well as crosstalk between them, plays a critical role in the establishment of the complex architecture of the vertebrate central nervous system. In this review, we explore the signalling networks triggered by non-canonical Wnt/receptor interactions, focussing on the emerging roles of the non-conventional Wnt receptors Ryk and Ror. We describe the role of these pathways in neural tube formation and axon guidance where Wnt signalling controls tissue polarity, coordinated cell migration and axon guidance via remodelling of the cytoskeleton.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Cell Movement
/
Wnt Signaling Pathway
/
Neurons
Limits:
Animals
Language:
En
Journal:
Neurosignals
Journal subject:
NEUROLOGIA
Year:
2012
Type:
Article
Affiliation country:
Australia