Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.

Doktorova, Tatyana Y; Ellinger-Ziegelbauer, Heidrun; Vinken, Mathieu; Vanhaecke, Tamara; van Delft, Joost; Kleinjans, Jos; Ahr, Hans-Juergen; Rogiers, Vera

Doktorova, Tatyana Y; Ellinger-Ziegelbauer, Heidrun; Vinken, Mathieu; Vanhaecke, Tamara; van Delft, Joost; Kleinjans, Jos; Ahr, Hans-Juergen; Rogiers, Vera.

Affiliation

Doktorova TY; Department of Toxicology, Center for Pharmaceutical Research, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. tatyana.yordanova.doktorova@vub.ac.be

Arch Toxicol ; 86(9): 1399-411, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22484513

Subject(s)

Carcinogens/toxicity; Gene Expression Regulation, Neoplastic/drug effects; Hepatocytes/metabolism; Liver Neoplasms, Experimental/metabolism; Liver/metabolism; Mutagens/toxicity; Neoplasm Proteins/metabolism; Animals; Carcinogenicity Tests/methods; Carcinogens/pharmacology; Cell Cycle/drug effects; Cells, Cultured; DNA Damage; Gene Expression Profiling; Hepatocytes/drug effects; Liver/drug effects; Liver Neoplasms, Experimental/chemically induced; Male; Mutagens/pharmacology; Neoplasm Proteins/genetics; Oligonucleotide Array Sequence Analysis; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Rats, Wistar; Toxicogenetics/methods

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinogens / Gene Expression Regulation, Neoplastic / Hepatocytes / Liver / Liver Neoplasms, Experimental / Mutagens / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Arch Toxicol Year: 2012 Type: Article Affiliation country: Belgium

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