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Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists.
Asano, Masayoshi; Nakamura, Tsuyoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Yamaguchi, Takahiro; Tamaki, Kazuhiko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nara, Futoshi; Kawase, Yumi; Masubuchi, Noriko; Nakayama, Shintaro; Koga, Tetsufumi; Namba, Eiko; Nasu, Hatsumi; Nishi, Takahide.
Affiliation
  • Asano M; Lead Discovery & Optimization Research Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Bioorg Med Chem Lett ; 22(9): 3083-8, 2012 May 01.
Article in En | MEDLINE | ID: mdl-22487179
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Thiazoles / Thiophenes / Receptors, Lysosphingolipid Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Thiazoles / Thiophenes / Receptors, Lysosphingolipid Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: Japan