Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.

Bos, Steffan D; Bovée, Judith V M G; Duijnisveld, Bouke J; Raine, Emma V A; van Dalen, Wouter J; Ramos, Yolande F M; van der Breggen, Ruud; Nelissen, Rob G H H; Slagboom, P Eline; Loughlin, John; Meulenbelt, Ingrid

Bos, Steffan D; Bovée, Judith V M G; Duijnisveld, Bouke J; Raine, Emma V A; van Dalen, Wouter J; Ramos, Yolande F M; van der Breggen, Ruud; Nelissen, Rob G H H; Slagboom, P Eline; Loughlin, John; Meulenbelt, Ingrid.

Affiliation

Bos SD; LUMC, Molecular Epidemiology, Einthovenweg 20, Leiden 2333 ZC, The Netherlands. s.bos@lumc.nl

Ann Rheum Dis ; 71(7): 1254-8, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22492780

Subject(s)

Cartilage, Articular/enzymology; Genetic Predisposition to Disease; Iodide Peroxidase/genetics; Osteoarthritis, Hip/genetics; Osteoarthritis, Knee/genetics; Polymorphism, Single Nucleotide; Adult; Aged; Aged, 80 and over; Female; Humans; Immunohistochemistry; Iodide Peroxidase/metabolism; Loss of Heterozygosity; Male; Middle Aged; Osteoarthritis, Hip/enzymology; Osteoarthritis, Hip/pathology; Osteoarthritis, Knee/enzymology; Osteoarthritis, Knee/pathology; Risk Factors; Severity of Illness Index; Iodothyronine Deiodinase Type II

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis, Hip / Cartilage, Articular / Osteoarthritis, Knee / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Iodide Peroxidase Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Ann Rheum Dis Year: 2012 Type: Article Affiliation country: Netherlands

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